Which non-motor symptom is commonly associated with Huntington's disease?

• A. Depression
• B. Seizures
• C. Hypertension
• D. Peripheral neuropathy

Answer: (A)

Mood and behavioral changes are a hallmark of Huntington’s disease, and depression is the most commonly reported non-motor symptom. The disease disrupts frontostriatal circuits that regulate mood, motivation, and affect, leading to depressive symptoms, irritability, and apathy even before or alongside motor signs. This mood disturbance significantly impacts quality of life and daily functioning, which is why it stands out as the best answer. Seizures are not a typical feature of Huntington’s, and hypertension or peripheral neuropathy do not reflect the characteristic non-motor profile of this condition.